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The segment or r is the t0 1st column in X The segment nwyd is the t1 4th column in X The segment Go.auy is the t2 0th column in X The segment dio o is the t3 3rd column in X The segment mg oa is the t4 5th column in X The segment onHet is the t5 2nd column in X

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it more vulnerable from a security perspective This is illustrative of the nature of the compromises that occur within protocol design, where optimizing one characteristic of a protocol may be at the expense of another bene t of the protocol Buffer congestion control mechanism As explained before, buffer congestion is a risk, especially in the downlink buffers of the bottleneck mobile network elements (eg 2GSGSN in (E)GPRS) Therefore, appropriate congestion control methods should be implemented in such network elements There exist several methods to control congestion: The most well-known standard buffer management method is probably the Random Early Detection (RED) The principle in RED is to increase the packet-dropping probability of incoming packets if the buffer occupancy grows Ultimately, if the buffer length exceeds a pre-de ned threshold, every incoming packet will be dropped.

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Fig. 14.5 Pressure as a function of baryon chemical potential for a two-phase ideal gas model of cold, strongly interacting matter (Satz, 1983).

The advantage of starting dropping packets before the buffer is completely full is to force some of the TCP sources to reduce their sending rate before congestion actually happens Another advantage is to avoid global synchronization of Internet routers Global synchronization happens when the router buffers load oscillate from almost empty to congested, and is caused mostly by TCP dynamic congestion control mechanism of different connections acting at the same time Fast-TCP The idea here is to start delaying slightly the TCP acknowledgments in the UL buffer of a router if the downlink buffer exceeds a de ned threshold As a result, the time at which the TCP sources will send their next window of data will be also delayed which gives more time to router buffers to recover from congestion.

Furthermore, delaying slightly the TCP acknowledgment will slow down the growth of the congestion window in the TCP sender, which is also bene cial in case of congestions The delay to apply to uplink TCP ACKs should be carefully computed since too large delays would cause TCP timeout in the TCP senders, which is not the objective..

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742 Cord Blood-Derived Stem Cells 7421 Hematopoietic Stem Cells HSC activities should be determined in two ways, in vitro and in vivo In vitro assays include the long-term culture-initiating cell (LTC-IC) assay, the cobblestone area-forming cell (CAFC) assay, the high proliferative potential colony-forming cell (HPP-CFC) assay, and the colony-forming unit-blast (CFU-BL) assays [Heike et al, 2002] The in vivo method uses the engraftment assay in nonobese diabetic/severe combined immunode cient (NOD/SCID) mice as described below Six- to eight-week-old mice irradiated with 270 cGy received 5 103 expanded cells via tail vein injection Mice were sacri ced at 10 12 weeks after the transplantation Femurs and tibiae were collected and aspirated with 5% FBS-containing PBSA to liberate mouse bone marrow.

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Cell suspensions were ltered through a sterile 40- m cell strainer to get rid of clumps and debris and were then processed for ow cytometric analysis Presence of at least 01% human CD45+ cells in mouse bone marrow after transplantation was considered proof of human cell engraftment [Leung et al, 2005] HSCs contain a small population of primitive and pluripotent stem cells that express a CD34+ cell surface marker pattern and are capable of self-renewal and generation of committed progenitors of myeloid and lymphoid compartments However, the number of HSCs in cord blood is limited Therefore, cord blood-derived HSCs after ex vivo expansion [Astori et al, 2005; Flores-Guzman et al, 2002] or coinfusion of two or more units can serve as a reliable resource for hematopoietic stem cell transplantation 7422 Cord Blood-Derived MSCs.

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