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In a quantity contract the quantity available in the contract is called the Target Quantity The quantity that has been consumed by call off orders is called the Order Quantity In Figure 4-1 we see a quantity contract with two line items with a target quantity of 10 pce for each line item, of which there are release orders of 3 and 4 pce As an example in the document flow for item 10 in this example, one can see the release order for 3 pce in Figure 4-2

August P Overview: mechanisms of hypertension: cells, hormones, and the kidney J Am Soc Nephrol 2004 Aug;15(8): 1971 3 [PMID: 15284282] Cowley AW Jr The genetic dissection of essential hypertension Nat Rev Genet 2006 Nov;7(11):829 40 [PMID: 17033627] Davies AA et al Association between birth weight and blood pressure is robust, amplifies with age, and may be underestimated Hypertension 2006 Sep;48(3):431 6 [PMID: 16880348] Freel EM et al Mechanisms of hypertension: the expanding role of aldosterone J Am Soc Nephrol 2004 Aug;15(8):1993 2001 [PMID: 15284285] Gentile CL et al Modest weight gain is associated with sympathetic neural activation in nonobese humans Am J Physiol Regul Integr Comp Physiol 2007 May;292(5):R1834 8 [PMID: 17218435] Grandi AM Antihypertensive therapy: role of aldosterone antagonists Curr Pharm Des 2005;11(17):2235 42 [PMID: 16026292] Lenders JW et al Phaeochromocytoma Lancet 2005 Aug 20 26;366(9486):665 75 [PMID: 16112304] Mulatero P et al Diagnosis of primary aldosteronism: from screening to subtype differentiation Trends Endocrinol Metab 2005 Apr;16(3):114 9 [PMID: 15808809] Rahmouni K et al Obesity-associated hypertension: new insights into mechanisms Hypertension 2005 Jan;45(1):9 14 [PMID: 15583075]

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are more closely correlated with systolic than diastolic blood pressure The incidence of these complications is markedly reduced by antihypertensive therapy Preceding hypertension is associated with a higher incidence of subsequent dementia of both vascular and Alzheimer types Effective blood pressure control may reduce the risk of development of cognitive dysfunction later in life, but once cerebral small vessel disease is established, low blood pressure might exacerbate this problem

Safar ME et al: Vascular development, pulse pressure, and the mechanisms of hypertension Hypertension 2005 Jul;46(1): 205 9 [PMID: 15911744] Strazzullo P et al Altered renal handling of sodium in human hypertension: short review of the evidence Hypertension 2003 May;41(5):1000 5 [PMID: 12668589] Textor SC Renovascular hypertension update Curr Hypertens Rep 2006 Dec;8(6):521 7 [PMID: 17087862]

Complications of hypertension are related either to sustained elevations of blood pressure, with consequent changes in the vasculature and heart, or to atherosclerosis that accompanies and is accelerated by long-standing hypertension Most of the adverse outcomes in hypertension are associated with thrombosis rather than bleeding, possibly because increased vascular shear stress converts the normally anticoagulant endothelium to a prothrombotic state The excess morbidity and mortality related to hypertension are progressive over the whole range of systolic and diastolic blood pressures; the risk approximately doubles for each 6 mm Hg increase in diastolic blood pressure However, target-organ damage varies markedly between individuals with similar levels of office hypertension; ambulatory pressures are superior to office readings in the prediction of end-organ damage

Chronic hypertension leads to nephrosclerosis, a common cause of renal insufficiency; aggressive blood pressure control attenuates the process In patients with hypertensive nephropathy, the blood pressure should be 130/80 mm Hg or lower, especially when proteinuria is present Secondary renal disease is more common in blacks, particularly when accompanied by diabetes mellitus Hypertension also plays an important role in accelerating the progression of other forms of renal disease, most commonly diabetic nephropathy

Hypertension is a contributing factor in many patients with dissection of the aorta Its diagnosis and treatment are discussed in 12

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